FCGR1A (Fc fragment of IgG, high affinity Ia, receptor (CD64))

Certainty Style Key

Certainty styling is being phased out topic by topic.

Hover over keys for definitions:
True   Likely   Speculative
What is MOCA?
MOCA FAQ...
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

The Fc fragment of IgG, high affinity la, receptor (FCGR1A) is a leukocyte IgG receptor that is expressed on most myeloid cells. FCGR1A binds IgG with high affinity to help mediate the immune response, although its exact role in immune response cell signaling is not clear. There are 3-4 more copies of FCGR1A in humans than in any other primate, although the significance of this higher copy number is not understood.

Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

  • the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
  • the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
  • the emergence of the genus Homo was 2,000 thousand (2 million) years ago
  • the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
  • the common ancestor of modern humans was 100 - 300 thousand years ago

Probable Appearance: 
2,000 thousand years ago
Definite Appearance: 
6,000 thousand years ago
Genetics Topic Attributes
Gene symbols follow the HUGO Gene Nomenclature Committee standard.
Gene Symbol Type of Human-Specific Changes
FCGR1A Copy Number Changes

References

  1. Functional characteristics of the high affinity IgG receptor, FcγRI., van der Poel, Cees E., Spaapen Robbert M., van de Winkel Jan G. J., and Leusen Jeanette H. W. , J Immunol, 2011 Mar 1, Volume 186, Issue 5, p.2699-704, (2011)
  2. Diversity of human copy number variation and multicopy genes., Sudmant, Peter H., Kitzman Jacob O., Antonacci Francesca, Alkan Can, Malig Maika, Tsalenko Anya, Sampas Nick, Bruhn Laurakay, Shendure Jay, and Eichler Evan E. , Science, 10/2010, Volume 330, Issue 6004, p.641-6, (2010)
  3. Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR., Armengol, Gemma, Knuutila Sakari, Lozano Juan-José, Madrigal Irene, and Caballín María-Rosa , Genomics, 2010 Apr, Volume 95, Issue 4, p.203-9, (2010)
  4. Lineage-specific gene duplication and loss in human and great ape evolution., Fortna, A., Kim Y., MacLaren E., Marshall K., Hahn G., Meltesen L., Brenton M., Hink R., Burgers S., Hernandez-Boussard T., et al. , PLoS Biol, 07/2004, Volume 2, Issue 7, p.E207, (2004)

© CARTA · All rights reserved.   Terms of Use · Privacy Policy · Site Map · Site Credits · Related Links · FAQ · Contact Us

UC San DiegoSalk