FGFR2 (fibroblast growth factor receptor 2)

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Human Uniqueness Compared to "Great Apes": 
No Difference
MOCA Domain: 

Fibroblast Growth Factor Receptor 2 (FGFR2) is a highly conserved tyrosine-protein kinase essential to embryonic development and patterning, as well as proliferation and tissue repair post-development. Known isoforms are shared with most other mammals, as is exon number and expression profile (De Moerlooze et al 2000, MGI). FGFR2-related mutations in humans have been capitulated in mice, with induced mutations in mice resulting in highly similar phenotypes. Overall, this FGF receptor does not appear to have significant differences between great apes and humans.

The Human Difference: 

 none known...

Genetics Topic Attributes


  1. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis., De Moerlooze, L, Spencer-Dene B, Revest J M., Hajihosseini M, Rosewell I, and Dickson C , Development, 2000 Feb, Volume 127, Issue 3, p.483-92, (2000)