FGFR2 (fibroblast growth factor receptor 2)

Fibroblast Growth Factor Receptor 2 (FGFR2) is a highly conserved tyrosine-protein kinase essential to embryonic development and patterning, as well as proliferation and tissue repair post-development. Known isoforms are shared with most other mammals, as is exon number and expression profile (De Moerlooze et al 2000, MGI). FGFR2-related mutations in humans have been capitulated in mice, with induced mutations in mice resulting in highly similar phenotypes. Overall, this FGF receptor does not appear to have significant differences between great apes and humans.