GLRA4 (Glycine receptor, alpha 4)
Certainty styling is being phased out topic by topic.Hover over keys for definitions:
The glycine receptor alpha 4 (GLRA4) is a human lineage specific processed pseudogene. Glycine receptors are membrane bound ligand-gated chloride channels mediated by glycine, which acts as an inhibitory neurotransmitter. Glycine receptors are pentameric channels composed of four alpha subunits and one beta subunit. Most mammals have 4 functional alpha subunit genes, however, in humans alpha 4 is a pseudogene. Implications for the loss of function of GLRA4 is unknown.
Novel expression of a functional glycine receptor chloride channel that attenuates contraction in airway smooth muscle., , FASEB J, 05/2011, Volume 25, Issue 5, p.1706-17, (2011)
Divergence, demography and gene loss along the human lineage., , Philos Trans R Soc Lond B Biol Sci, 2010 Aug 27, Volume 365, Issue 1552, p.2451-7, (2010)
Molecular structure and function of the glycine receptor chloride channel., , Physiol Rev, 10/2004, Volume 84, Issue 4, p.1051-95, (2004)