MC1R (melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) )

Certainty Style Key

Certainty styling is being phased out topic by topic.

Hover over keys for definitions:
True   Likely   Speculative
Human Uniqueness Compared to "Great Apes": 
Absolute Difference
MOCA Domain: 
MOCA Topic Authors: 

Melanocortin, a pituitary peptide hormone, stimulate melanocytes.  Melanocortin 1 receptor, or MC1R, is G protein-coupled receptor for melanocortin.  Nonfunctional MC1R gene was found to be responsible for mice light pigmentation (Robbins et al., 1993).  Later, Harding et al. (2000) showed that this gene polymorphism is related to pigmentation in human too.

Related MOCA Topics
Related Topics (hover over title for reason):
Referenced By:
Topic Certainty
Hairlessness
Genetics Topic Attributes
Gene symbols follow the HUGO Gene Nomenclature Committee standard.
Gene Symbol Type of Human-Specific Changes
MC1R Polymorphism

References

  1. Evidence for variable selective pressures at MC1R., Harding, R M., Healy E, Ray A J., Ellis N S., Flanagan N, Todd C, Dixon C, Sajantila A, Jackson I J., Birch-Machin M A., et al. , Am J Hum Genet, 2000 Apr, Volume 66, Issue 4, p.1351-61, (2000)
  2. Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function., Robbins, L S., Nadeau J H., Johnson K R., Kelly M A., Roselli-Rehfuss L, Baack E, Mountjoy K G., and Cone R D. , Cell, 03/1993, Volume 72, Issue 6, p.827-34, (1993)