PAK2 (p21 activated kinase 2)

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Human Uniqueness Compared to "Great Apes": 
Likely Difference
Human Universality: 
Individual Universal (All Individuals Everywhere)
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p21 protein (Cdc42/Rac)-activated kinase 2 (PAK2) is a serine/threonine kinase that is a target for the GTP binding proteins CDC42 and RAC1. PAK2 likely plays a role in regulating apoptosis and may be involved in neurite outgrowth. PAK2 has more copies in the human genome than in any other primate.

Genetics Topic Attributes
Gene symbols follow the HUGO Gene Nomenclature Committee standard.
Type of Human-Specific Changes
Copy Number Changes


  1. CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons., Demyanenko, G P., Halberstadt A I., Rao R S., and Maness P F. , Neuroscience, 01/2010, Volume 165, Issue 1, p.107-15, (2010)
  2. Lineage-specific gene duplication and loss in human and great ape evolution., Fortna, A., Kim Y., MacLaren E., Marshall K., Hahn G., Meltesen L., Brenton M., Hink R., Burgers S., Hernandez-Boussard T., et al. , PLoS Biol, 07/2004, Volume 2, Issue 7, p.E207, (2004)