TDH (L-threonin dehydrogenase)
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L-Threonine Dehydrogenase (TDH) is a human lineage specific expressed pseudogene. In organisms where TDH is functional, it catalyzes the first two steps in one of two L-threonine degredation pathways by conversion of L-threonine to glycine. In humans, 3 mutations in the gene lead to a truncated non-functional protein and as such humans degrade L-threonine via the alternative pathway.
Divergence, demography and gene loss along the human lineage., , Philos Trans R Soc Lond B Biol Sci, 2010 Aug 27, Volume 365, Issue 1552, p.2451-7, (2010)
The human L-threonine 3-dehydrogenase gene is an expressed pseudogene., , BMC Genet, 2002 Oct 2, Volume 3, p.18, (2002)