MBL1P (mannose-binding lectin (protein A) 1, pseudogene)

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What is MOCA?
MOCA FAQ...
Human Uniqueness Compared to "Great Apes": 
Likely Difference
MOCA Domain: 
Genetics
MOCA Topic Authors: 
Majesta O'Bleness
James Sikela

Mannose-binding lectin 1 (MBL1) is a member of the collectin family and is involved in binding multiple types of microorganisms to activate the lectin-complimentary pathway of innate immunity. Most mammals, including rodents and primates have two MBL genes, 1 and 2, however MBL1 has become a pseudogene in the human lineage. Implications for this loss are not understood.

Timing

Timing of appearance of the difference in the Hominin Lineage as a defined date or a lineage separation event. The point in time associated with lineage separation events may change in the future as the scientific community agrees upon better time estimates. Lineage separation events are defined in 2017 as:

  • the Last Common Ancestor (LCA) of humans and old world monkeys was 25,000 - 30,000 thousand (25 - 30 million) years ago
  • the Last Common Ancestor (LCA) of humans and chimpanzees was 6,000 - 8,000 thousand (6 - 8 million) years ago
  • the emergence of the genus Homo was 2,000 thousand (2 million) years ago
  • the Last Common Ancestor (LCA) of humans and neanderthals was 500 thousand years ago
  • the common ancestor of modern humans was 100 - 300 thousand years ago

Possible Appearance: 
4,500 thousand years ago
Definite Appearance: 
6,000 thousand years ago
Genetics Topic Attributes
Gene symbols follow the HUGO Gene Nomenclature Committee standard.
Gene Symbol Type of Human-Specific Changes
MBL1P Pseudogenization

References

  1. Divergence, demography and gene loss along the human lineage., Kim, Hie Lim, Igawa Takeshi, Kawashima Ayaka, Satta Yoko, and Takahata Naoyuki , Philos Trans R Soc Lond B Biol Sci, 2010 Aug 27, Volume 365, Issue 1552, p.2451-7, (2010)
  2. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates., Zhang, Zhengdong D., Frankish Adam, Hunt Toby, Harrow Jennifer, and Gerstein Mark , Genome Biol, Volume 11, Issue 3, p.R26, (2010)
  3. Molecular genetic analysis of porcine mannose-binding lectin genes, MBL1 and MBL2, and their association with complement activity., Phatsara, C, Jennen D G. J., Ponsuksili S, Murani E, Tesfaye D, Schellander K, and Wimmers K , Int J Immunogenet, 02/2007, Volume 34, Issue 1, p.55-63, (2007)
  4. Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes., Sastry, R, Wang J S., Brown D C., Ezekowitz R A., Tauber A I., and Sastry K N. , Mamm Genome, 02/1995, Volume 6, Issue 2, p.103-10, (1995)

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