Cellular and Molecular Explorations of Anthropogeny

Event Dates: 
Sep 29, 2017 -
1:00pm to 5:30pm

The complete genome sequences of our closest existing and extinct relatives are now readily available. This has not only made possible the identification of positions in the genome where we are similar to chimpanzees and other apes but also reveals where and how all present-day humans, no matter where they live on the planet, are identical to each other but different from Neandertals. Since the genetic differences between these species are those that set modern humans apart from all other organisms on the planet, the identification of these unique positions constitutes an essentially complete “genetic recipe” for being a modern human. A major challenge for the next decade is to identify which of these genetic changes had important consequences, in particular with respect to the cognitive and social abilities that have made the development of rapidly changing technology, large societies, art, and perhaps modern language possible. Understanding the meaning of these differences is a crucial undertaking to fully explain the human condition and to address the diseases and other conditions that affect traits that are unique to humans. The development of the process of generating induced pluripotent stem cells from somatic cells, which can then be differentiated into any cell or tissue type, allows investigators to establish cellular and organ-specific systems to identify functionally important genetic differences occurring through primate evolution. The further establishment of specific gene-editing tools increases the precision through with these studies can reveal important changes. This symposium will be the first of its kind to explore the progress being made in this new area of Cell and Molecular Anthropogeny.

Event Sessions

Date Session Title Speakers Location
Fri 9/29 Making faces: Regulatory and evolutionary principles in the development of the human neural crest. Joanna Wysocka Salk Institute - Conrad T. Prebys Auditorium
Fri 9/29 Cell-autonomous differences in cerebral cortex progenitor cell proliferative behaviors contribute to increased human brain size compared with primates and other mammals Rick Livesey Salk Institute - Conrad T. Prebys Auditorium
Fri 9/29 Emergence of a Homo sapiens-specific gene families Evan Eichler Salk Institute - Conrad T. Prebys Auditorium
Fri 9/29 Developmental and pathological changes in the organization and functions of the cell nucleus Martin Hetzer Salk Institute - Conrad T. Prebys Auditorium
Fri 9/29 Genomic changes that are responsible for the increase in neuron number in the human neocortex as compared to other primates Wieland Huttner Salk Institute - Conrad T. Prebys Auditorium
Fri 9/29 Cellular and Molecular underpinnings of human brain development Arnold Kriegstein Salk Institute - Conrad T. Prebys Auditorium
Fri 9/29 What are the genetic mechanisms that led to the evolution of human cortical circuits? Franck Polleux Salk Institute - Conrad T. Prebys Auditorium
Fri 9/29 A cellular and molecular approach to research into the biological basis of the human condition Svante Pääbo Salk Institute - Conrad T. Prebys Auditorium
Fri 9/29 Cellular and molecular mechanisms that differentiate human and non-human neural development Fred Gage Salk Institute - Conrad T. Prebys Auditorium
Registration

Registration Deadline: Friday, September 29, 2017 at 1:00 PM

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