Publication Type: Journal Article
Authors: Winckler, W.; Myers, S. R.; Richter, D. J.; Onofrio, R. C.; McDonald, G. J.; Bontrop, R. E.; McVean, G. A. T.; Gabriel, S. B.; Reich, D.; Donnelly, P.; Altshuler, D.
Year of Publication: 2005
Date Published: 04/2005
Publication Language: eng
Keywords: Alleles, Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Chromosomes, Mammalian, Evolution, Molecular, Genome, Genome, Human, Genotype, Globins, Haplotypes, HLA Antigens, Humans, Linkage Disequilibrium, Markov Chains, Monte Carlo Method, Pan troglodytes, Polymorphism, Single Nucleotide, Recombination, Genetic, Sequence Homology, Nucleic Acid
We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.
Alternate Journal: Science