APOC1 (apolipoprotein C-I)
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Apolipoprotein C-I (APOC1) is a member of the apolipoprotein family which are proteins that reside on surface of lipoproteins, where one side interacts with the aqueous environment of the blood and the other with the hydrophobic interior of the lipid core. On chromosome 19 of great apes there are two apoC-I genes; one encodes a positively charged 57 amino acid protein and the other a negatively charged 57 amino acid protein, however humans lack an active apoC-IA gene due to the presence of a stop codon in the third exon. In the other great apes, there is no stop codon and the apoC-IA gene encodes an acidic apolipoprotein. Because there is only the basic form in humans, the suffix B is not used. APOC1 has been shown to play an important role in brain function and in prevention of coronary artery disease through its regulation of triglyceride metabolism. It is possible that the pseudogenization of one copy of APOC1 may have some impact on human rates of coronary artery disease.
Apolipoprotein CI knock-out mice display impaired memory functions., , J Alzheimers Dis, 2011, Volume 23, Issue 4, p.737-47, (2011)
The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis., , J Lipids, 2011, Volume 2011, p.271062, (2011)
Detection of two distinct forms of apoC-I in great apes., , Comp Biochem Physiol Part D Genomics Proteomics, 2010 Mar, Volume 5, Issue 1, p.73-9, (2010)
Baboon apolipoprotein C-I: cDNA and gene structure and evolution., , Genomics, 1992 Jun, Volume 13, Issue 2, p.368-74, (1992)
Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene., , J Biol Chem, 1988 May 25, Volume 263, Issue 15, p.7277-86, (1988)