CARTA Glossary
Word | Definition | Related Vocabulary |
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"Archaic" Homo sapiens |
Earlier forms of Homo sapiens who were anatomically and behaviorally distinct from modern humans. |
Homo sapiens |
Allele |
Alternative DNA sequence at the same locus (location on the chromosome) |
DNA sequence |
American Sign Language (ASL) |
A natural language that serves as the predominant sign language of Deaf communities in the United States and most of Anglophone Canada. |
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Ancestral Variant |
A genetic variant (e.g.: single-nucleotide polymorphism, SNP, or a larger change) representing the ancestral state and coexisting with more recent variants |
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Basal Ganglia (Brain) |
Subcortical nuclei in the base of the forebrains of vertebrates, including humans, which are involved with a variety of functions including control of voluntary motor movements, procedural learning, and routine behaviors or “habits” such as teeth grinding, eye movements, cognition, and emotion. |
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Biallelic |
Pertaining to both alleles (both alternative forms of a gene). |
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Bonobos (Pan paniscus) |
One of the two species comprising the genus, Pan, having branched from chimpanzees ~1 million years ago. Sometimes referred to as “pygmy chimpanzee.” Bonobos, compared to chimpanzees, are more gracile, have female social dominance, relatively long legs, pink lips, a dark face, a “tail-tuft” through adulthood, and parted long head hair. The species is omnivorous and inhabits primary and secondary forests, including seasonally inundated swamp forests. The bonobo is found in a 500,000 km2 (190,000 sq mi) area of the Congo Basin, only south of the Congo River, in the Democratic Republic of the Congo. Due to political instability, little field work in their natural habitat has been performed. Most behavioral knowledge is a result of studies of captive bonobos. |
Chimpanzees (Pan troglodytes), Genus, Species |
Carcinoma |
A type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. Carcinomas are abnormal cells that divide without control and can spread to other parts of the body. |
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Chimpanzees (Pan troglodytes) |
One of the two species comprising the genus, Pan, having branched from bonobos ~1 million years ago. Sometimes referred to as “common chimpanzees”. Native to sub-Saharan Africa, chimpanzees are found in and around the Congo Basin (north of the Congo River) and throughout West Africa. Chimpanzees are divided into four subspecies, based on appearance and distribution. Compared to bonobos, chimpanzees are somewhat larger, more aggressive, and exhibit male social dominance. |
Bonobos (Pan paniscus), Genus |
Chromatin |
A complex of DNA and proteins (histone and adaptor proteins) forming chromosomes. |
Protein |
Cognitive Trade-off Hypothesis |
As proposed by Tetsuro Matsuzawa, postulates that a trade-off between superior language facility at the expense of memory ability based on social life occurred during human evolution. In comparison to chimpanzees, who possess superior short-term memory abilities and no known language, humans de-emphasized short term memory for extraordinary language capacity, which may be one mechanism for increased collaboration and altruism in humans. |
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Combinatorial Phonology |
A universal property of human language in which a set of basic, distinct units (phonemes, syllables, or hand shapes) can be combined in many different ways. |
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Complex Trait |
A phenotypic trait with variability influenced by numerous genes (each with small effects). |
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Copy number variation (CNV) |
A phenomenon in which sections of the genome are repeated on the same or different chromosome and the number of repeats in the genome varies between individuals in the human population. Such repeats can include functional genes. |
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Culture |
Behavior and norms that are shared, learned, and socially transmitted. |
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de Novo |
A Latin adverb meaning “from the new.” A new genetic variant that is the result of a mutation in a germ cell (egg or sperm) of one of the parents, or a variant that arises in the fertilized egg during embryogenesis. (See Novel) |
Embryogenesis, Novel (disease) |
Dental Calculus |
Calcified dental plaque, provides information on diet, disease, health, microbiome and protects the genetic information within the tooth from degradation. |
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DNA methylation |
A process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription. |
Molecule, Transcription |
Dual Inheritance |
A theory that human behavior is a product of two different and interacting evolutionary processes: genetic evolution and cultural evolution. Genes and culture continually interact in a feedback loop. |
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Ecology |
The interaction of organisms with their physical environment, along with other organisms. |
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Epigenetics |
A term first coined by the developmental biologist, Conrad Waddington, in 1942 to explain how a singular genotype might produce variations in phenotype across development. He argued that some level of regulation must exists “above” or “over” genes to determine when and where they are expressed. Today the term refers to stable alterations in gene expression without changes to the underlying DNA sequence. |
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Foraging |
Searching for wild food or provisions as opposed to cultivating food crops or breeding livestock. |
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Gene-Culture Co-Evolution Theory |
A branch of theoretical population genetics that models the transmission of genes and cultural traits from one generation to the next, exploring how they interact. Also known as “biocultural evolution” or “biological enculturation” (feedback between culture and biology). |
Biological enculturation |
Genome Wide Association Study (GWAS) |
An approach for “gene mapping” in which hundreds of thousands of SNPs are tested statistically for genetic associations with a phenotype. |
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Gyrification |
The process of forming the characteristic folds of the cerebral cortex. The peak of such a fold is called a gyrus (plural: gyri), and its trough is called a sulcus (plural: sulci). |
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Heritability |
A statistic used in the fields of breeding and genetics that estimates the degree of variation in a phenotypic trait in a population that is due to genetic variation between individuals in that population. |
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Hippocampus (Brain) |
A part of the limbic system that plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation. Humans and other vertebrates have two hippocampi, one in each side of the brain. It is named after its resemblance to the shape of a sea horse (hippocampus in Latin). |
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Histone Modification |
A covalent post-translational modification (PTM) to histone proteins which includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. |
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Human Accelerated Regions (HARs) |
A set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans. They are named according to their degree of difference between humans and chimpanzees. Some of these highly mutated areas may contribute to human-specific traits while others may represent “loss of function” mutations, possibly due to the action of biased gene conversion rather than adaptive evolution. |
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Hunting and gathering |
A subsistence strategy in which most or all food is obtained by foraging and is in contrast to agriculture, which rely mainly on domesticated species. |
Agriculture, Foraging |
Inter-birth intervals |
The time span between live births. |
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Mircofossils |
Fossils or fossil fragments of bacteria, protists, fungi, animals, and plants (e.g.: starch granules) that can only be seen with a microscope. |
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Morphology (Linguistics) |
The sub-discipline of linguistics concerned with the structure and parts of words (stems, root words, prefixes, and suffixes), how words are formed, and their relationship to other words in the same language. Parts of speech, intonation and stress, and contextual pronunciation and meaning are aspects of Morphology. |
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Mycobacterium tuberculosis |
The pathogenic bacteria that causes tuberculosis. |
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Neocortex |
A part of the cerebral cortex concerned with sight, hearing, and touch in mammals, regarded as the most recently evolved part of the cortex. |
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Odds Ratio (in GWAS) |
The ratio between the odds of individuals having a phenotype associated with a specific allele and the odds of the same phenotype for individuals who do not have that same allele. |
Genome Wide Association Study (GWAS) |
Ontogeny |
The origin and development of an organism (from fertilization of the egg to the organism’s mature form). Can also refer to the study of an organism’s lifespan. |
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Optogenetic |
A biological technique that involves the use of light to control gene expression and cellular function in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels. |
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Phonology (Linguistics) |
The organization of the sounds or signs in language. |
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Primates |
A group of mammals that include humans, apes, monkeys, and prosimians. |
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Radial Glia |
A primary progenitor cell capable of generating neurons, astrocytes, and oligodendrocytes. Radial glia are defined by their position, morphology, and genetic phenotype. These cells are involved in establishing a temporary scaffold for cortical layer development. |
Basal Radial Glia, Basal Ganglia (Brain), Outer Radial Glia |
Scavengers |
Organisms that search for and feed on carrion, dead plant material, or refuse. |
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Semantics (Linguistics) |
The study of the logic and meaning of a word, phrase, sentence, or text. |
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Social Referencing |
A process where an individual takes cues from other people in the environment, about which emotions and actions are appropriate in a certain context or situation. |
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Stable Isotope |
Isotopes that do not decay into other elements. These isotopes, found in biological material, including fossils, and can be used to study paleo-diet and ecology. |
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Structural variation (Genomics) |
The variation in structure of an organism’s chromosomes. It consists of many kinds of variation in the genome of one species, and usually includes microscopic and submicroscopic types, such as deletions, duplications, copy-number variants, insertions, inversions and translocations that are greater than or equal to 50 base pairs in length. |
Copy number variation (CNV), Species |
Syntax |
The arrangement of words and phrases to create well-formed sentences in a language. |
Language (human) |
Tinbergen's Four Questions |
Nikolaas Tinbergen’s 1962 paper “On aims and methods of Ethology,” defined complementary categories for analyzing and explaining animal behavior as proximate (developmental: both ontogenic and mechanistic) and ultimate (evolutionary: both phylogenetic and adaptive).
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Variation (Biology) |
The differences among the individuals of the same species. |
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Working Memory |
The part of short-term memory that is concerned with immediate conscious perceptual and linguistic processing. It is also important for reasoning and the guidance of decision-making and behavior. |
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Yersinia pestis |
The gram-negative bacterium that causes the plague, which takes three main forms: pneumonic, septicemic and bubonic. |