Large-scale recent expansion of European patrilineages shown by population resequencing.

Bibliographic Collection: 
Publication Type: Journal Article
Authors: Batini, Chiara; Hallast, Pille; Zadik, Daniel; Delser, Pierpaolo Maisano; Benazzo, Andrea; Ghirotto, Silvia; Arroyo-Pardo, Eduardo; Cavalleri, Gianpiero L; de Knijff, Peter; Dupuy, Berit Myhre; Eriksen, Heidi A; King, Turi E; López de Munain, Adolfo; López-Parra, Ana M; Loutradis, Aphrodite; Milasin, Jelena; Novelletto, Andrea; Pamjav, Horolma; Sajantila, Antti; Tolun, Aslıhan; Winney, Bruce; Jobling, Mark A
Year of Publication: 2015
Journal: Nat Commun
Volume: 6
Pagination: 7152
Date Published: 2015
Publication Language: eng
ISSN: 2041-1723
Keywords: Bayes Theorem, Biological Evolution, Computer Simulation, Demography, DNA, Mitochondrial, Emigration and immigration, Ethnic groups, Europe, European Continental Ancestry Group, Genetic Variation, Genetics, Population, Genomics, Geography, Haplotypes, History, Ancient, Humans, Male, Middle East, Mutation, Phylogeny, Population Dynamics, Sequence Analysis, DNA

The proportion of Europeans descending from Neolithic farmers ∼ 10 thousand years ago (KYA) or Palaeolithic hunter-gatherers has been much debated. The male-specific region of the Y chromosome (MSY) has been widely applied to this question, but unbiased estimates of diversity and time depth have been lacking. Here we show that European patrilineages underwent a recent continent-wide expansion. Resequencing of 3.7 Mb of MSY DNA in 334 males, comprising 17 European and Middle Eastern populations, defines a phylogeny containing 5,996 single-nucleotide polymorphisms. Dating indicates that three major lineages (I1, R1a and R1b), accounting for 64% of our sample, have very recent coalescent times, ranging between 3.5 and 7.3 KYA. A continuous swathe of 13/17 populations share similar histories featuring a demographic expansion starting ∼ 2.1-4.2 KYA. Our results are compatible with ancient MSY DNA data, and contrast with data on mitochondrial DNA, indicating a widespread male-specific phenomenon that focuses interest on the social structure of Bronze Age Europe.

DOI: 10.1038/ncomms8152
Alternate Journal: Nat Commun