Mature haploid sex cells that can unite to form a diploid zygote.
A genus of Gram-variable-staining facultative anaerobic bacteria of which Gardnerella vaginalis is the only species.
|Gardnerella vaginalis, Genus, Gram-Negative and Gram-Positive Staining|
A facultatively anaerobic Gram-variable rod that is involved, together with many other bacteria, in bacterial vaginosis in some women as a result of a disruption in the normal vaginal microflora.
|Bacterial Vaginosis (BV), Gram-Negative and Gram-Positive Staining|
Inflammation of the stomach and small intestine typically caused by a virus, but can also be caused by bacteria, parasites, and fungi. Symptoms may include diarrhea, vomiting, and abdominal pain.
|Bacteria, Inflammation, Parasite, Virus|
A DNA sequence which encodes a specific function.
|DNA, DNA sequence, Post-translation Modifications, Translation|
A type of concerted evolution where one gene on a chromosome can “paste” its sequence over a neighboring gene of high sequence similarity such that the sequences become identical after the conversion event. This phenomenon is common between similar genes located on the same chromosome region.
The process by which the information contained within a gene (nucleotide sequence) is used to direct protein synthesis and dictate cell function. Nearly all of the cells in the body contain identical genes, but only a subset of this information is used or expressed at any time. The genes expressed in a cell determine what that cell can do.
Movement of alleles between populations as is achieved by mating.
The total of all genes and their variants (alleles) of a population of a species.
|Allele, Gene, Species|
Alterations of gene expression/activity.
|IncRNA, miRNA, RNA Binding Proteins (RBP), Transcription Factor Proteins|
|Gene-Culture Co-Evolution Theory||
A branch of theoretical population genetics that models the transmission of genes and cultural traits from one generation to the next, exploring how they interact. Also known as “biocultural evolution” or “biological enculturation” (feedback between culture and biology).
|Biological enculturation, Gene|
A combination of medications that put you in a sleep-like state before medical procedures.
A biological characteristic with a heritable basis that improves reproduction and/or survival and results from evolution by natural selection.
The total of heritable traits within a species.
Change in allele frequencies, including fixation and loss, by chance.
The presence of deleterious gene variants (including recessive variants) in a population.
A version of a DNA sequence that differs from others found at the same locus. For example, the difference can consist in a single base pair (as in single nucleotide polymorphisms, SNP) or in the deletion/insertion of a DNA base(s). See: indel.
|DNA, Indel, Locus (pl. loci), Single Nucleotide Polymorphism (SNP)|
The study of genes and their inheritance.
A person who is exceptionally intelligent or creative, either generally or in some particular respect.
The totality of DNA in a cell. Also refers to the DNA sequence that typifies an individual or species.
|DNA, DNA sequence, Genetics, Genomics, Species|
|Genome Wide Association Study (GWAS)||
An approach for “gene mapping” in which hundreds of thousands of SNPs are tested statistically for genetic associations with a phenotype.
Modification of the genome at the level of DNA (e.g. methylation) or its packaging into chromatin (histone tail modification via phosphorylation, acetylation, ubiquitination or glycosylation).
The study of genome structure/function.
The two alleles at one or more diploid loci.
Characterizing genetic variants at one or more loci.
A taxonomic rank used in biological classification of living and fossil organisms to group closely related species. In binomial nomenclature, the genus name plus species name forms the binomial species name (e.g. Homo sapiens).
|Homo sapiens, Species|
|Germinal Zone||A region where cell division and proliferation occurs during vertebrate central nervous system development consisting of 2 layers lining the ventricles (ventricular zone and subventricular zone).|
|Glia (aka Neuroglia)||
Non-neuronal cells in the central nervous system and the peripheral nervous system that do not produce electrical impulses. Their function is to ensure homeostasis, form myelin, and provide support and protection for neurons. Glia make up ~50% of our brain cells.
|Central nervous system (CNS), Myelin Sheaths, Neuron|
|Global Neuronal Workspace (GNW)||
A hypothesis that offers a simple connectomic scheme based upon the contribution of neurons with long-range axons to conscious processing. Their reciprocal interactions contribute to the formation of a global workspace, broadcasting signals from the sensory periphery to the whole brain, thus yielding “conscious” experience. The GNW hypothesis privileges cortical pyramidal cells with long-range excitatory axons, particularly dense in prefrontal, temporoparietal, and cingulate regions, that, together with the relevant thalamocortical loops, reciprocally interconnect multiple specialized, automatic, and non-conscious processors. Another important feature of this hypothesis is that the GNW activates in a non-linear manner, called ‘‘ignition,’’ upon access to conscious processing. Ignition is characterized by the sudden, coherent, and exclusive activation of a subset of workspace neurons coding for the current conscious content, with the remainder of the workspace neurons being inhibited.
|Global nitrogen cycle||
The biogeochemical cycle by which nitrogen is converted by fixation (gaseous nitrogen is converted into ammonia, which can be taken up by plants), ammonification (organic nitrogen from decaying animal and plant matter is converted into ammonium by bacteria and fungi), nitrification (ammonium is converted into nitrate by soil bacteria), and denitrification (nitrate is reduced into gaseous nitrogen). This cycle is central to the biogeochemistry of the Earth. Oceans also have an enormous nitrogen cycle.
A class of corticosteroids that are involved in stress response and are also a part of the feedback mechanism in the immune system. E.g., Dexamethasone (a synthetic glucorticoid).
One of the four classes of major biomolecules. Glycans consist of varying numbers of sugars (monosaccharides) attached to proteins or lipids or secreted as free glycans. Glycans are essential biomolecules whose functions can be divided into three broad categories: structural and modulatory properties (including nutrient storage and sequestration), specific recognition by other molecules, and molecular mimicry of host glycans.
|Lipid, Monosaccharides, Protein|
A type of a lipid (fat) with an attached glycan that functions to maintain the stability of the cell membrane and to facilitate cellular recognition. Glycolipids are crucial in immune response and tissue formation.
A class of proteins with covalently attached glycans. Glycoproteins play a part in important cellular functions like embryonic development, cell-to-cell recognition, cell adhesion, and immune functions.
Proteins with enzymatic functions that are involved in adding monosaccharides to other molecules.
|Molecule, Monosaccharides, Protein|
|Gram-Negative and Gram-Positive Staining||
A characterization of bacteria based on how they differentially react with a chemical stain (crystal violet) based on their cell wall constituents.
An explanation of the post- menopausal life stage of human females whereby the existence of grandmothers serves as a biological and social adaptive advantage for humans. Post-reproductive life stages are non-existent among non-human primates, so it is hypothesized that humans evolved to have grandmothers and grandmothering to have individuals who are free to invest their energy into the offspring of their children. This off-loads the reproductive cost of parenting through social kin-networking, and off-set the resource cost of brain- building as parents are freed to provision resources. Increased resource procurement may reduce the inter-birth interval by allowing for earlier weening, which in turn increases offspring production potential, passes down generational knowledge, and increase social networks. In doing so, the grandmother ensures the survival of her genes in subsequent generations. The extended post-reproduction life stage of grandmothers likely had the added output of producing grandfathers, who also provide benefits to the extended family, as well as their own extended reproductive time line that competes with subsequent generations.
|Gray Matter (Brain)||
A major component of the central nervous system that includes regions of the brain involved in muscle control, sensory perception such as seeing and hearing, memory, emotions, speech, decision making, and self-control. Gray matter development peaks the third decade in humans.
The development and dissemination of crop variants and technology between the 1950s and 1960s that increased agricultural production around the world. Also known as the third agricultural revolution.
The entrapment of heat close to Earth’s surface by greenhouse gas emissions.
|Greenhouse gas emissions|
|Greenhouse gas emissions||
The release of polluting gasses resulting from human activity, such as burning fossil fuels that contribute to greenhouse effect.
|Grey ceiling effect||
The proposed boundary of maximum brain size in hominins that can be supported by an ape-like lifestyle that was crossed by genus Homo through the adoption of cooperative breeding. Described by Isler and van Schaik (2011).
|Guillain–Barré Syndrome (GBS)||
A rapid-onset muscle weakness caused by an autoimmune response in which the body’s immune system mistakenly attacks and damages the peripheral nervous system. Initial symptoms typically begin in the feet and hands with changes in sensation, pain, and muscle weakness, which then spreads to the arms and upper body of both sides. Sometimes this immune dysfunction is triggered by an infection or, less commonly by surgery, and rarely by vaccination.
|Autoimmunity, Immune system, Infection|
The process of forming the characteristic folds of the cerebral cortex. The peak of such a fold is called a gyrus (plural: gyri), and its trough is called a sulcus (plural: sulci).
A ridge on the cerebral cortex that, along with surrounding sulci (furrows) creates the folded appearance of the brain in humans and other mammals.
|Cerebral Cortex (Brain), Sulcus (Brain)|
An indigenous ethnic group of traditionally nomadic hunter-gatherers from the central Rift Valley and Serengeti Plateau of Tanzania. Tourism, encroachment by pastoralists, and land rights disputes critically threaten their way of life.
A prehistoric stone tool with two faces and is usually made from flint, basalt, sandstone, quartzite, or chert.
A set of similar haplotypes that share a common ancestor.
One set of unpaired chromosomes.
|Chromosome, Diploid, Karyotype|
A set of alleles along neighboring positions on a chromosome that are inherited together.
A map of informative subsets of single nucleotide polymorphisms (SNPs) found along a stretch of a chromosome used to identify blocks of genetic variation existing along human chromosomes.
|Chromosome, Single Nucleotide Polymorphism (SNP)|
Differences in the burden of disease, injury, violence, and health care as experienced by socially disadvantaged populations.
|Hematopoietic stem cells||
Stem cells that can become different types of blood cells.
One of two paired chromosomes is affected by a deletion. The other chromosome is intact.
A protein complex within red blood cells (RBCs) that binds to oxygen molecules in the lungs for delivery to tissues throughout the body. The same complex also binds carbon dioxide (CO2) and carries it back to the lungs.
|Protein, Erythrocytes (red blood cells - RBCs)|
The abnormal hemoglobin protein in red blood cells (RBCs) that causes RBCs to assume a sickle, or crescent shape.
|Hemoglobin, Erythrocytes (red blood cells - RBCs)|
|Hemoglobin Subunit Beta Gene (HBB)||
A gene that provides instructions for making beta-globin, a protein component of hemoglobin. Sickle Cell Anemia is a disorder caused by a mutation in the HBB gene.
|Gene, Hemoglobin, Mutation, Sickle Cell Anemia|
Sometimes also called “herd protection” or “indirect immunity,” this is when most of a population is immune to a specific contagious disease, which slows its spread to others that are not immune. However, because the level needed to reach this kind of immunity is so high (about 80-90% of the population), it invariably means that a lot of individuals must be infected (and often can die) before herd immunity can be achieved.
A statistic used in the fields of breeding and genetics that estimates the degree of variation in a phenotypic trait in a population that is due to genetic variation between individuals in that population.
Tightly wrapped and inactive chromatin.
Have two different alleles at a locus.
The back limbs and feet of a quadrupedal animal (also, the lower limbs/legs of a human).
A digestive process in which cellulose and other polysaccharides are broken down by symbiotic bacteria residing the colon of some mammalian species.
A part of the limbic system that plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation. Humans and other vertebrates have two hippocampi, one in each side of the brain. It is named after its resemblance to the shape of a sea horse (hippocampus in Latin).
Meaning “tissue-related”, these blood group antigens originally evolved on epithelial cells prior to expression on erythrocytes (red blood cells). ABO is a classic example of a histo-blood group.
|ABO blood groups, Antigen, Epithelial cells, Erythrocytes (red blood cells - RBCs)|
|Histone Deacetylase Inhibitor (HDACi)||
A drug that inhibits histone deacetylases or molecules involved in modifying histone proteins. Histone deacetylases typically function to reduce chromatin accessibility and gene expression. Therefore, administration of this drug allows for higher levels of gene expression.
A covalent post-translational modification (PTM) to histone proteins which includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers.
Chief protein components of chromatin and can be chemically modified as part of epigenetics.
The current geological epoch, from about 11.7 kya (after the end of the last Ice Age cycle) to the present that is marked by globally warmer and more stable climates.
The state of steady internal, physical, and chemical conditions maintained by living organisms.
A classification comprising all living and extinct “Great Apes” and humans.
A classification of species comprising humans and our extinct relatives following the split with the common ancestor with chimpanzees.
The genus that comprises the species Homo sapiens, as well as several extinct species classified as ancestral to, or closely related to, humans.
An extinct hominin species with fossil evidence from at least 1.9 million years to 70 thousand years ago and found from Africa to Indonesia. H. erectus may have been the first hominin to leave Africa. H. erectus DNA may be retrievable from other species due to archaic admixture.
|Archaic admixture, DNA, Hominin, Species|
An extinct archaic species of the genus Homo dating to ~2.1 to 1.5 mya. H. habilis means “handy man” and was named so because of its association with stone tools. H. habilis has intermediate morphology between Australopithecus and Homo erectus. There is ongoing debate if H. habilis should be moved to the Australopithecus genus. Initial discovery was made by Mary and Louis Leakey at Olduvai Gorge in Tanzania between 1962 and 1964.
An extinct hominin species whose fossil evidence dates to 335-236 kya. An assemblage of 15 H. naledi skeletons were first found in the Dinaledi Chamber of the Rising Star cave system in 2013 (since then, a second chamber has been found with H. naledi skeletons). The fossils possess a mix of “archaic” traits similar to genus Australopithecus (e.g. cranial and pelvic morphology) and “modern” traits characteristic of genus Homo (e.g. hand morphology). H. naledi lived contemporaneously with anatomically modern humans, Neanderthals, and Denisovans but is not likely a direct ancestors of humans living today.
The hominin species comprising all living humans. Meaning “wise man” in Latin, the name was introduced by Carl Linnaeus in 1758. The earliest fossil evidence of Homo sapiens appears in Africa around 300 kya (see Jebel Irhoud Hominins).
|Hominin, Jebel Irhoud hominins, Species|
Similarity in DNA or phenotype because of shared evolutionary history from a common ancestor.
Similarity in DNA sequence or phenotype that has evolved independently.
Have two identical alleles at a locus
A signaling molecule in multicellular organisms that contributes to the regulation of physiology and behavior.
A living organism on or in which a parasite, pathogen, commensal or symbiont lives (see Parasitism).
|Parasite, Parasitism, Pathogen, Symbionts|
A lithic technology cultural period in the Middle Stone Age in Africa named after the Howieson’s Poort Shelter archeological site near Grahamstown, South Africa. Dates range from ~65.8 kya to 59.5 kya. Examples include composite weapons hafted with ochre and gum compound glue and microlith blades, bone arrows, and needles.
|Human Accelerated Regions (HARs)||
A set of 49 segments of the human genome that are conserved throughout vertebrate evolution but are strikingly different in humans. They are named according to their degree of difference between humans and chimpanzees. Some of these highly mutated areas may contribute to human-specific traits while others may represent “loss of function” mutations, possibly due to the action of biased gene conversion rather than adaptive evolution.
|Human Arcuate Fasciculus||
The specialized connections composed of axons linking Broca’s area and Wernicke’s area in the human brain and is a major anatomic feature supporting language function in humans.
|Axon (nerve fiber), Broca’s Area, Wernicke’s area|
|Hunting and gathering||
A subsistence strategy in which most or all food is obtained by foraging and is in contrast to agriculture, which rely mainly on domesticated species.
The idea that hunting of large game by males provided sufficient provisions for themselves, their mates and offspring, while allowing for the reduction of female workloads, enhancement of fertility, and favoring of the later ages at maturity needed to learn and perfect essential skills. But modern data show that large animal prey would not have provided the reliable energy stream the argument requires.
|Age at maturity|
Breeding among recognized species.
An enzyme involved in the first step of aerobic oxidation of organic compounds.
A lack of early childhood exposure to infectious agents, symbiotic microorganisms and parasites believed to increase susceptibility to allergies and autoimmune diseases.
Increased sensitivity to pain.
Pain, hypohedonia, dysphoria, anxiety, hyperalgesia, irritability, and sleep disturbances associated with drug abstinence following excessive drug taking.
|Dysphoria, Hyperalgesia, Hypohedonia|
A neuropeptide that regulates arousal, wakefulness, and appetite.
A diminished capacity for pleasure.
A condition characterized by less than the normal amount of oxygen reaching the tissues; also, low partial pressure of oxygen at high elevations (hypobaric hypoxia).
A class of lectins belonging to the immunoglobulin superfamily. e.g., Siglecs
A sign that shares perceived physical properties with the thing it refers to (its “referent”) (Kluender, 2020).
A mode of behavior or way of thought peculiar to an individual.
Behavior copying. This term has been used to mean everything from social learning in general to the reproduction of action intentions but is now most commonly used in the narrow sense of copying the form or topography of observed movements.
|Immediate Return Hunter-Gatherers||
Those who do not store food, but consume it within a day or two of obtaining it. This means there is no opportunity to accumulate surplus.