|N-glycolylneuraminic acid (Neu5Gc)||
A common variant of sialic acid in many vertebrates that is not made by humans but can be incorporated from diets rich in red meat.
|Natural Antibodies (NAb)||
A type of antibody that exists in the absence of active immunization via infection and/or contact with fetal antigens during pregnancy as a first line of defense until a specific antibody response is mounted.
An extinct Eurasian hominin species that existed from 500-30 kya and interbred with ancient humans and Denisovans.
|Denisovans, Hominin, Species|
A response or behavior that is strengthened by stopping, removing, or avoiding a negative outcome or aversive stimulus.
The failure to provide for the development of the child in all spheres: health, education, emotional development, nutrition, shelter, and safe living conditions (including protecting the child from harm). It is the most common form of child maltreatment. In rodents, neglect it is similarly defined as inconsistent care, failure to group displaced infants in the nest, infant avoidance and failure to protect infants from harm or potential harm.
A part of the cerebral cortex concerned with sight, hearing, and touch in mammals, regarded as the most recently evolved part of the cortex.
The new growth of cells proliferating without regard to stop signals and with attendant new blood vessels that forms a neoplasm.
A tumor mass, either benign (not cancer) or malignant (cancer), that is composed of cells that have lost their regulatory checks and multiply without control or do not undergo pre-programmed cell death.
|Nerve||A bundle of fibers that transmits impulses of sensation to the brain or spinal cord, and impulses from these to the muscles and organs.|
The network of nerve cells and fibers that transmits nerve impulses between parts of the body.
A neural circuit is a functional entity of interconnected neurons that is able to regulate its own activity using a feedback loop.
|Neural Progenitor Cell||
Cells that are capable of dividing a limited number of times and have the capacity to differentiate into a restricted repertoire of neuronal and glial cell types.
|Basal Radial Glia, Basal Ganglia (Brain), Daughter Neuron, Neuron, Outer Radial Glia|
|Neural Stem Cell||A self-renewing, multipotent cell that generates the neurons and glia of the nervous system of all animals during embryonic development. Some persist in the adult vertebrate brain and continue to produce neurons throughout life.|
The study of the morphology, behavior, and other qualities of the nervous system.
The process by which neural stem cells (NSCs) produce neurons.
The study of the role of genetics in the development and function of the nervous system.
Relating to the anatomy, functions, and organic disorders of nerves and the nervous system.
A subset of neurotransmitters that regulate diverse populations of other neurons.
A specialized cell that transmits nerve impulses.
The ability of the brain to form and reorganize synaptic connections through growth and reorganization. These changes include new neural connections and cortical remapping resulting from learning, environmental influences, practice, and psychological stress.
The study of the relationship between behavior, emotion, and cognition and brain function.
A type of chemical messenger that transmits signals across a chemical synapse, such as a neuromuscular junction, from one neuron (nerve cell) to another “target” neuron, muscle cell, or gland cell.
A chemical released by nerve cells to send signals to other cells.
A membrane receptor protein that is activated by a neurotransmitter.
Not displaying or characterized by autistic or other neurologically atypical patterns of thought or behavior.
A bundle of fibers that transmits impulses of sensation to the brain or spinal cord, and impulses from these to the muscles and organs.
A form of ecological inheritance in which organisms alter the environment in ways that affect the developmental context and selection pressures acting on subsequent generations.
A natural alkaloid and insecticide produced by several plant species (tobacco and jimson weed). It also functions as a central nervous system stimulant as an analog of the neurotransmitter acetylcholine.
|Central nervous system (CNS), Neurotransmitter|
|Nicotinic acetylcholine receptor||
A receptor polypeptide that responds to the neurotransmitter, acetylcholine, and also responds to nicotine.
|Non-Hormonal Basis of Maternal Care||
The finding that care giving behavior can occur in female rats and mice that have not reproduced themselves through repeated exposure to infants.
The use of various techniques, such as Functional Magnetic Resonance Imaging, to image the structure, function, or pharmacology of the nervous system.
|Functional Magnetic Resonance Imaging (fMRI)|
Depression that is not related to changes in the seasons.
So called “smart drugs” or cognitive enhancers that are claimed to improve cognitive function. E.g., Modafinil.
A hormone and neurotransmitter that mobilizes the brain and body for action.
A new strain of a disease that has not been previously identified in a species. (See de Novo)
|de Novo, Species|
|Nuclear Pore Complex||Protein and ribonucleoprotein transport channels in the nuclear envelop of eukaryotic cells. Evolved ~ 1.5 billion years ago. While the primary role of NPCs is to regulate nucleo–cytoplasmic transport, recent research suggests that certain NPC proteins have additionally acquired the role of affecting gene expression at the nuclear periphery and in the nucleoplasm in metazoans.|
One of the four classes of major biomolecules. The overall name for DNA and RNA, which are composed of nucleotides.
|DNA, Nucleotide, Ribonucleic Acid (RNA)|
|Nucleoporin 98 (Nup98)||A protein coding gene that plays a role in the nuclear pore complex assembly and/or maintenance. Associated diseases range from Myelodysplastic Syndrome and Acute Monocytic Leukemia.||Nuclear Pore Complex|
Glycosylamines corresponding to nucleotides lacking a phosphate.
Molecular building blocks for DNA and RNA Specifically, they consist of three components: a 5-carbon sugar, a phosphate group, and a nitrogenous base. The type of sugar, either deoxyribose or ribose, determines if the resulting nucleic acid is DNA or RNA.
|DNA, Nucleic acid, Ribonucleic Acid (RNA)|
Exact symbolic quantifier that designates the cardinality of a collection of objects. It is abstract (i.e., it transcends perceptual modalities), relational, and operable. In its most prototypical case it is associated with the familiar counting sequence ‘1, 2, 3, . . . ’
A sign for a number, such as the Hindu-Arabic digit ‘5’, the Roman ‘V’, or the French word ‘cinq’, that signify the number five.
A scale of measurement for evaluating the numerousness of stimuli (e.g., a collection of discriminable objects) utilized especially by psychophysicists in the mid-20th century, and by means of which an experimenter establishes the cardinal attribute of physical collections of objects.
A property or attribute of a stimulus (discrete quantities) which can be measured by an investigator in units of numerosity.
Excessive body fat that increases the risk of health problems. Defined as a Body Mass Index (BMI) of 30.0 or higher.
|Obligate Tool User||
Tool use is a necessity for survival. Tool use is an essential part of being human and we are the only known obligate tool users.
A biological constraint of bipedalism and large fetal brains imposed on the human female pelvis.
|Odds Ratio (in GWAS)||
The ratio between the odds of individuals having a phenotype associated with a specific allele and the odds of the same phenotype for individuals who do not have that same allele.
|Genome Wide Association Study (GWAS)|
|Oldowan (Mode 1)||
A stone tool type characterized by simple “choppers” for pounding, breaking, and bashing. ~2.6 - 1.7 mya.
|Olfactory Bulb (Brain)||
A neural structure of the vertebrate forebrain involved in sense of smell.
A type of neuroglia that supports and insulates axons in the central nervous system of some vertebrates.
|Axon (nerve fiber), Central nervous system (CNS), Glia (aka Neuroglia)|
An organism that derives its energy and nutrient requirements from a diet of plant, animal, and fungal origin.
The origin and development of an organism (from fertilization of the egg to the organism’s mature form). Can also refer to the study of an organism’s lifespan.
An almost universally human cognitive bias that seems to cause individuals to believe that they are at less risk of experiencing a negative event and more likely to experience a positive outcome compared to other people.
A biological technique that involves the use of light to control gene expression and cellular function in living tissue, typically neurons, that have been genetically modified to express light-sensitive ion channels.
|Organoid||Cell/tissue culture in vitro that aims to mimic organ structure and function.|
|Out of Africa||
A hypothesis proposing the geographic origins of the genus Homo in Africa and migration of anatomically modern humans. These anatomically modern humans would have completely replaced the archaic human populations (Neanderthals, Denisovans, etc.) that had previously left Africa. This hypothesis emphasizes the African origin of our species but allows for the possibility of minor local contributions from archaic populations.
|Outer Radial Glia||
Found in the outer subventricular zone of the neocortex, outer radial glia preferentially express genes related to extracellular matrix formation, migration, and stemness.
|Outer Subventricular Zone||A uniquely structured germinal zone that generates the expanded primate supragranular layers.|
Forming a close relationship with another individual through courtship and sexual activity.
Related membrane proteins that have similar extracellular appearance but opposite signaling functions and are found in pairs or clusters primarily on immune cells.
A broad prehistoric period during which stone was used to make tools and weapons and is synonymous with Stone Age. Subdivisions:
An epidemic that has spread across regions, including multiple continents or worldwide.
A genus of extinct bipedal hominins dating to ~ 2.6 mya to 1.1 mya that lived throughout eastern and south Africa. Their robust cranialdental anatomy suggests an adaptation to a diet of tough vegetation. Possible tool use is indicated by hands adapted for precision grasping. They probably descended from the gracile australopithecine hominids (Australopithecus) ~2.7 million years ago, hence their alternative name, robust australopithecine, and ongoing debate on genus.
An organism that lives on or in a host organism at the expense of the host.
A close relationship between two organisms where one benefits at the expense of the other.
Any behavior of a member of a species toward an immature conspecific that increases the likelihood that the immature organism will survive to maturity.
The sex with the lower rate of reproduction invests more in parental effort than in mating effort.
The investment of resources (time, energy, provisions) into offspring.
|Parental Investment Theory||
The correlation between parental investment and mate choice where the greater the parental investment the more selective, and the lesser the investment the greater the access to more mates (Trivers, 1972).
|Parietal Lobe (Brain)||
One of the major lobes in the human brain, roughly located at the upper back in the skull (“crown”). It processes sensory information such as touch, taste, and temperature, spatial senses and navigation (proprioception), and language processing.
A bacterium, virus, or other microorganism that can cause disease.
The biological mechanism (or mechanisms) that leads to a disease state and can also refer to the origin and development of a disease, and whether it is acute, chronic, or recurrent.
The absolute ability of an infectious agent to cause disease or damage in a host.
|Host, Infectious (disease)|
Disordered physiological processes associated with disease or injury.
|Peer Review (Academic Publishing)||
The professional critique by other scholars or scientists from the same field that normally takes place before scholarly or scientific papers are accepted for publication.
The ability to see, hear, or become aware of something through the senses.
Depression that occurs during pregnancy.
|Peyote (Lophophora williamsii)||
A small, spineless cactus with psychoactive alkaloids (mescaline) that is native to Mexico and southwestern Texas.
Observable traits of an organism that result from interactions between genes and environment during development.
The sound patterns of language.
A branching diagram showing the evolutionary relationships among biological species, or other entities, based on their physical or genetic characteristics.
Historical relationships of species or loci.
A compromise between different physiological needs of body functions.
A branched chain fatty acid produced during the digestion of chlorophyll, especially in foregut fermenting species (ruminants) that consume plant materials. Humans obtain phytanic acid by consuming dairy products, ruminant animals, and some fish.
|Chlorophyll, Foregut fermentation|
|Phytanic Acid Metabolism (in humans)||
Eating ruminants (red meat and dairy) creates special demands on detoxifying metabolism as phytanic acid (lipids) from plants eaten by ruminants can be toxic to humans.
A genus of single-celled organisms that are obligate parasites of vertebrates and insects. In humans, malaria is caused by multiple species of Plasmodium and transmitted by mosquitos (commonly female Anopheles mosquitos).
|Anopheles Mosquitos, Genus, Malaria, Parasite|
The adaptability of an organism to changes in its environment or differences between its various habitats.
A geological epoch from ~2.5 mya to 11.7 kya characterized by a period of repeated glaciations. The end of the Pleistocene corresponds with the end of the last glacial period and also with the end of the Paleolithic age used in archeology. Subdivisions:
A bacterium that infects the lungs and sometimes the blood stream.
The idea that some genes are more easily expressed because of their chromatin state.
Relating to a trait determined by two or more genes. Most traits of organisms are polygenic.
|Polymerase chain reaction (PCR)||
A method of copying a specified locus.
The “many forms,” or genetic variants, of a single gene that exist and are maintained in a population at a frequency of 1% or higher.
|Allele Frequency, Derived Alleles, Fixed Alleles, Gene, Variant|
A homopolymer of sialic acids abundant in the brain and fish eggs and found on certain pathogenic bacteria.
|POM121||A gene that encodes for transmembrane nucleoporin, a protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus.|
A defined group of similar individuals among whom interbreeding occurs.
|Demography, Gene Flow|
|Positron Emission Tomography (PET) Neuroimaging||
A functional imaging technique used to observe metabolic process in the body.
Alter mature protein.
|Posterior Parietal Cortex||
The portion of parietal neocortex that plays an important role in planned movements, spatial reasoning, and attention.