CARTA Glossary
| Word | Definition | Related Vocabulary |
|---|---|---|
| Hunter-gatherers |
People whose livelihood relies on foraging: hunting animals, fishing, and gathering wild plants and other resources for sustenance. |
Foraging |
| Hunting and gathering |
A subsistence strategy in which most or all food is obtained by foraging and is in contrast to agriculture, which rely mainly on domesticated species. |
Agriculture, Foraging |
| Hunting hypothesis |
An explanation for the dietary shift to meat procurement during human evolution as a catalyst favoring a suite of transformative biological and behavioral adaptations. |
|
| Hybridization |
Breeding among recognized species. |
Species |
| Hydroxylase |
An enzyme involved in the first step of aerobic oxidation of organic compounds. |
Enzyme |
| Hygiene Hypothesis |
A lack of early childhood exposure to infectious agents, symbiotic microorganisms and parasites believed to increase susceptibility to allergies and autoimmune diseases. |
|
| Hyperalgesia |
Increased sensitivity to pain. |
|
| Hyperandrogenism |
A medical condition in females characterized by excess levels of androgens, male sex hormones, such as testosterone. |
|
| Hyperkatifeia |
Pain, hypohedonia, dysphoria, anxiety, hyperalgesia, irritability, and sleep disturbances associated with drug abstinence following excessive drug taking. |
Dysphoria, Hyperalgesia, Hypohedonia |
| Hypermethylation |
The increase or abnormal addition of methyl groups (–CH3) to DNA, typically at cytosine bases in CpG dinucleotides. This chemical modification is a key epigenetic mechanism that can influence gene expression without altering the underlying DNA sequence. |
Deoxyribonucleic acid (DNA) |
| Hypoallergenic |
Having a decreased tendency to provoke an allergic reaction. |
|
| Hypocretin (Orexin) |
A neuropeptide that regulates arousal, wakefulness, and appetite. |
|
| Hypohedonia |
A diminished capacity for pleasure. |
|
| Hypoxia |
A condition characterized by less than the normal amount of oxygen reaching the tissues; also, low partial pressure of oxygen at high elevations (hypobaric hypoxia). |
|
| I-type lectins |
A class of lectins belonging to the immunoglobulin superfamily. e.g., Siglecs |
Immunoglobulins, Lectin |
| Iberomaurusian |
A type of lithic industry featuring a backed bladelet specific to the coasts of Morocco, Algeria, and Tunisia dating between 25,000 and 11,000 years ago. |
|
| Icon |
A sign that shares perceived physical properties with the thing it refers to (its “referent”) (Kluender, 2020). |
|
| Idiosyncrasy |
A mode of behavior or way of thought peculiar to an individual. |
|
| Imitation |
Behavior copying. This term has been used to mean everything from social learning in general to the reproduction of action intentions but is now most commonly used in the narrow sense of copying the form or topography of observed movements. |
|
| Immediate Return Hunter-Gatherers |
Those who do not store food, but consume it within a day or two of obtaining it. This means there is no opportunity to accumulate surplus. |
|
| Immune Cells |
Cells that are part of the immune system. Most develop from stem cells in the bone marrow and become different types of white blood cells (the microglia of the brain originate in the yolk sack during embryonic development). Immune cells are broadly classified into innate and adaptive immune cells. Innate immune cells include neutrophils, basophils, mast cells, monocytes and eosinophils, dendritic cells, and macrophages. Adaptive immune cells include B-cells and T-cells. T-Cells and Natural Killer T-cells mediate important dialogues between innate (rapid) and adaptive (slower) immune responses. B-cells and T-cells can form long- term immunological memory. |
B-cells (B lymphocyte), Immune system |
| Immune system |
The biological defense system of an organism that protects against disease. |
|
| Immunity |
The capability of multicellular organisms to resist harmful microorganisms from entering it and compromising its biological systems. The balanced state of adequate biological defenses to fight infection, disease, or other unwanted biological invasion, while having adequate tolerance to avoid allergy, and autoimmune diseases. It critically relies on recognition of both self and non-self. |
Autoimmune disease, Multicellularity |
| Immunoglobulin domain/fold (Ig) |
A type of region (domain) present in many different proteins that is self-stabilizing and folds independently. |
Protein |
| Immunoglobulins |
A type of protein that forms antibodies and other receptors both on cell surfaces and as soluble proteins of vertebrates. Comprised of a massive superfamily, immunoglobulins perform many different functions, including recognition, binding, or adhesion processes of cells. |
Antibody, Glycoprotein, Immune system, Protein |
| Immunology |
The branch of biology and biomedicine concerned with the study of immune systems. |
Immune system |
| Immunoreceptor tyrosine-based activation motif (ITAM) |
A highly conserved region in the cytoplasmic domain of signaling chains of adapter proteins and receptors and typically result in activation of inflammatory responses. |
|
| Immunoreceptor tyrosine-based inhibitory motif (ITIM) |
A conserved sequence of amino acids, including phosphorylated tyrosine, that is found intracellularly in the cytoplasmic domains of many inhibitory receptors. |
Amino acids |
| IncRNA |
Long non-coding microRNA |
Gene regulation |
| Indel |
An insertion or deletion of a DNA sequence. |
DNA sequence, Mutation |
| Index |
A sign that depends for its reference on the physical presence of the thing that it refers (its “referent”) to at some point in space and time (e.g. smoke, a weather vane, a bullet hole, your index finger) (Kluender, 2020). |
|
| Induced pluripotent stem cells (iPSC) |
Somatic (body) cells that are artificially reprogrammed to an embryonic-like stem cell state and differentiated into other types of cells. |
|
| Industrial revolution |
The transition from agrarian and handcraft manufacture of goods to large scale industrial production starting 1760 in Great Britain and the United States. |
|
| Infant care |
The practices and activities involved in ensuring the health, safety, and well-being of a newborn or young child, including feeding, hygiene, comfort, and emotional nurturing. |
|
| Infanticide | The killing of infants by males or females. | |
| Infection |
The invasion of an organism’s organs or tissues by pathogens, their multiplication, and the reaction of the host tissues to the pathogens. |
Host, Pathogen |
| Infectious disease |
The capability of producing infection or spreading disease to others. Synonymous with communicable and transmissible. |
Communicable (disease), Infection, Transmissible (Disease) |
| Inferior Frontal Gyrus (Brain) |
The lowest positioned gyrus of the frontal gyri, of the frontal lobe, and is part of the prefrontal cortex. It is located in Broca’s area, which is involved in language processing and speech production. |
Broca’s Area, Frontal lobe (brain), Gyrus (Brain), Pre-frontal cortex (brain) |
| Inferior Temporal Cortex (Brain) |
The cerebral cortex on the inferior convexity of the temporal lobe in primates, including humans and is It is crucial for visual object recognition. |
Cerebral Cortex (Brain) |
| Infibulation |
A procedure that partially closes the inner or outer labia across the urethral meatus and vaginal opening through cutting, suturing, or sealing to leave a smooth scar. |
|
| Inflammation |
An often-painful localized redness, swelling, and heat that is the body’s response to an injury or infection. While uncomfortable, it indicates that your body is working hard to repair itself or to defend against infection. |
|
| Inflammatory diseases |
Conditions that involve a prolonged or excessive immune response, leading to inflammation in the body. |
|
| Influenza |
Often referred to as “flu,” this is a highly contagious viral respiratory illness. Symptoms include fever, severe body aches, and catarrh. Because it is so contagious, influenza often produces epidemics. There are several influenza viruses that affect humans (A, B, C) - all enveloped RNA viruses. |
Catarrh, Contagious (disease), Epidemic, Respiratory, Ribonucleic acid (RNA) |
| Inhibitory neurotransmitter |
A chemical messenger that decreases the likelihood that the neuron will fire an electrical signal called an action potential (see also excitatory neurotransmitter). |
Excitatory neurotransmitter |
| Insertion |
In piercing, the act of putting jewelry into an existing pierced channel, often with the aid of an insertion taper. |
Insertion taper, Piercing |
| Insertion taper |
A tapered tool that is designed to facilitate the process of inserting jewelry into a piercing. |
Piercing |
| Intentionality |
The power of minds to be about, to represent, or to stand for, things, properties and states of affairs. Refers to the ability of the mind to form representations and should not be confused with intention. Beliefs about others’ beliefs display what is sometimes known as “higher-order intentionality.” |
|
| Inter-birth interval |
The amount of time between consecutive births. |
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| Interactive synchrony |
Temporal coordination of behavior, physiology, neural activity, and/or mental representations between individuals. |
|
| Interbirth interval (IBI) |
The amount of time between consecutive births. |
|
| Internal feedback model |
A proposition in which some of a system’s output is returned through the input for processing, which allows the system to make adjustments in the output. |
|
| Internal model (motor control) |
A process that stimulates the response of the system in order to estimate the outcome of a system disturbance. |
|
| Intersectional neuroscience framework |
A research framework that adapts procedures to be more inclusive of underrepresented groups through community engagement with diverse participants and individualized methods to accommodate neural diversity. |
|
| Intracellular Signaling Cascade |
The series of sequential events that transmit signals received at the surface of a neuron to internal regulatory molecules, which are then modified by the signal. These pathways allow external signals from the environment to regulate gene expression. |
|
| Intrauterine Life |
The interval of life between conception and birth. |
|
| Introgression |
Transfer of alleles between species. |
Allele, Species |
| Introns |
Sequences between eons, don't encode proteins |
Exon, Locus |
| Intuition |
A thing that one knows or considers likely from instinctive feeling rather than conscious reasoning. |
|
| Invasive species |
A non-indigenous organism that can destabilize ecosystems when introduced. |
|
| Isoflurane |
A potent inhalational anesthetic used for induction and maintenance of general anesthesia. Works via GABA receptors. |
GABA receptors |
| Isotope |
Each of two or more forms of the same element that contain equal numbers of protons but different numbers of neutrons in their nuclei, and hence differ in relative atomic mass but not in chemical properties; in particular, a radioactive form of an element. |
|
| Isotopic Signature |
The ratio of non-radiogenic “stable isotopes,” stable radiogenic isotopes, or unstable radioactive isotopes of particular elements in an investigated material. |
|
| Japanese Encephalitis |
An infection of the central nervous system caused by the Japanese Encephalitis Virus. Most infections are benign but occasionally can cause inflammation of the brain (encephalitis), headaches, vomiting, fever, confusion and seizures. |
Inflammation, Japanese Encephalitis Virus (JEV), Nervous system |
| Japanese Encephalitis Virus (JEV) |
A RNA virus of the genus Flavivirus that causes Japanese Encephalitis and is generally spread by mosquitoes, such as Aedes mosquitos. JEV is prevalent in much of Asia and the Western Pacific. Pigs and wild birds serve as a reservoir for the virus. |
Aedes Mosquitos, Genus, Japanese Encephalitis, Reservoir (Medicine), RNA virus, Virus |
| Jaundice |
A yellowing of the eyes and skin due to rapid breakdown of red blood cells (RBCs) and release of degraded hemoglobin. |
Hemoglobin, Erythrocytes (red blood cells - RBCs) |
| Jebel Irhoud hominins |
The oldest known “early” human fossils discovered, dating to roughly 300,000 years ago from an archaeological site in Morocco. The location of this discovery suggests a “pan-African” origin of humans, with a dispersed interbreeding population, likely aided by climactic factors. |
|
| John Ssebunya of Uganda |
In 1989, at age 4-5, he witnessed his father murder his mother and subsequently fled into the Ugandan jungle. He was accepted as a peripheral member of a group of vervet monkeys who cared for and nourished him for a period of two years. He was found and captured in 1991. |
|
| Ju/’hoansi |
An indigenous population of San people in northeastern Namibia and northwestern Kalahari desert region of Botswana. |
San People |
| Kabwe skull (Broken Hill skull) |
A fossilized human cranium dated to approximately 300,000–125,000 years ago, that was discovered in 1921 in Kabwe (formerly Broken Hill), Zambia. It is classified as Homo heidelbergensis or sometimes as an archaic Homo sapiens. The skull has a large braincase of about 1,230 cubic centimeters but also retains robust features, such as a prominent brow ridge, broad face, and thick cranial bones. The Kabwe Skull may represent a transitional form between Homo erectus and later anatomically modern humans. |
"Archaic" Homo sapiens, Anatomically "Modern" Humans, Homo erectus, Homo heidelbergensis |
| Kalambo Falls, Zambia |
An important archaeological site in Africa with a sequence of human activity over 250,000 years. Kalambo Falls is located in northeastern Zambia, along the border with Tanzania. |
|
| Karyotype |
Chromosome number in the cell nucleus. |
Diploid, Haploid |
| Kazakh steppe |
A vast semi-arid grassland region in Central Asia, covering much of northern and central Kazakhstan and extending into parts of Russia, Uzbekistan, and China. It is part of the larger Eurasian Steppe, a continuous belt of grasslands stretching from Eastern Europe to Mongolia. |
Eurasian Steppe |
| KDM8 |
A gene that encodes a lysine demethylase enzyme and plays a crucial role in epigenetic regulation via histone demethylation, influencing gene expression, chromatin structure, and cellular function. Studies have shown a role in tumor suppression. |
Chromatin, Epigenetic regulation, Gene, Gene expression, Histones |
| Kessler Syndrome |
A state in which the accumulation of space-debris in low Earth orbit causes a cascade of collisions with space vehicles and other orbital objects (satellites) results in more space debris, rendering parts of space unusable for human purposes. Proposed by Donald J. Kessler in 1978. |
|
| Khoisan (or Khoe-Sān) |
A collective term for non-Bantu indigenous people of South Africa, as well as for the related languages they speak. |
|
| Kinematics |
A description of the motion of objects; how the limbs and joints, or combinations of these bodies, move during a particular type of locomotion. |
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| Kinetics |
A description of the forces acting on a body; the forces the body exerts (or resists) during locomotion. |
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| Klasies-River |
A river and cave system in the Tsitsikamma coast, Humansdorp district, Eastern Cape Province, South Africa. Evidence for middle stone age-associated human habitation has been found in the nearby cave system dating to ~125 kya. |
|
| Konso-Gardula |
A palaeoanthropological area in the southern Main Ethiopian Rift that was discovered 1991 The Konso-Gardula sediments span ~ 1.9 mya to 1.3 mya. Early Homo fossils and Acheulean stone tools have been found here. |
|
| KYA |
Thousand years ago. |
|
| Labia stretching |
The lengthening of the inner or outer labia through a regimen of pulling and stretching, often with herbs. Formerly included in the World Health Organization (WHO) typology of female genital modifications. Also known as “labia minora elongation,” or LME. |
Female Genital Modification (FGM), Stretching |
| Labiaplasty |
A plastic surgery to cut and remove part of the genital labia, often to reduce the inner labia so they are contained behind the outer labia. |
|
| Lactation |
The process of producing and secreting milk from the mammary glands. |
|
| Lactobacillus |
A genus of Gram-positive, rod-shaped bacteria that convert sugars to lactic acid. In humans, they are a significant component of the microbiome and can survive in the harsh pH conditions of the digestive and genital systems. Lactobacillus species are normally a major part of the vaginal microbiota. While receiving nutrients from their human host, Lactobacilli protect the host against certain pathogens, even helping to treat diarrhea, vaginal infections, and skin disorders such as eczema. Lactobacillus is the most common probiotic, perhaps most notable for its use in yogurt. |
Bacteria, Genus, Gram-Negative and Gram-Positive Staining, Infection, Microbiome, Pathogen, Species, Vaginal Microbiome |
| Lactobacillus crispatus |
A common genus of beneficial Lactobacillus bacteria that produces hydrogen peroxide (H202) and is found in the vagina and gastrointestinal system. |
Bacteria, Genus |
| Lactobacillus iners |
A common genus of beneficial Lactobacillus bacteria that normally inhabits the lower reproductive system and vagina of healthy women. |
Bacteria, Genus |
| Language (human) |
A structured system of communication that is generative (combine words/symbols to convey an infinite number of ideas), recursive (builds upon itself without limit), and has displaced reference (describe things not present). |
Displaced reference, Recursion (Language) |
| Large language models (LLMs) |
Machine learning algorithms that can recognize, summarize, translate, predict, and generate human languages on the basis of very large text-based datasets. |
|
| Large quantity discrimination (LQD) |
The rough discrimination of collections of discrete items above the subitizing range, whose numerosities usually differ by a substantial amount. |
Numerosity, Subitizing |
| Last Glacial Maximum (LGM) |
The Last Glacial Maximum occurred about 20,000 years ago (or more specifically between 24,000 and 18,000 years BP) during the last phase of the Pleistocene Epoch, when the global sea level was some 125 meters lower than it is today, due to the sea water being locked up as glaciers and ice sheets, and having reached their maximum total mass during the last ice age. The climate was much colder and drier. |
Before present (BP), Pleistocene |
| Late Bloomers |
Individuals from high-risk backgrounds who begin to manifest resilience later in adolescence or adulthood following a period of maladjustment or problems. |
|
| Late-night wake therapy (LWT) |
A sleep schedule therapy hypothesized to relieve peripartum depression by altering melatonin and sleep timing (sleep from 9:00 pm - 01:00 am). |
Peripartum depression |
| Lectin |
A protein that can bind to a glycan without catalyzing a modification of the glycan. |
Glycans, Protein |
| Legumes |
Plants in the Fabaceae family that include beans, peas, chickpeas, peanuts, lentils, alfalfa, and clover, to name a few. Many legumes have a symbiotic association with nitrogen-fixing bacteria. They also tend to have large, protein-rich seeds. |
|
| Levallois Technique (prepared core) |
A method of creating stone tools by first striking flakes off the stone, or core, along the edges to create the prepared core and then striking the prepared core in such a way that the intended tool is flaked off with all of its edges pre-sharpened. |
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| Lexeme |
A basic unit of lexical meaning core to set of related words (play, plays, playing, played, player, with play as the lexeme). |
|
| Lexical semantics |
Word meanings. |
|
| Lexicon (Linguistics) |
The vocabulary of a person, language, or branch of knowledge. |
|
| Lies |
Untrue stories the teller wants the listener to believe. |
Story |
| Life History |
The schedule of life, including birth to sexual maturity, duration of the reproductive period, duration of the post-reproductive period (if there is one), and mortality rate at each stage. |

