A natural alkaloid and insecticide produced by several unrelated plant species (coffee, tea, and cacao). It also functions as a central nervous system stimulant that reversibly blocks the action of adenosine on its receptors.
|Adenosine, Central nervous system (CNS), Receptor|
The set of chemical reactions that take place in chloroplasts of plants during photosynthesis. This light-independent process converts carbon atoms from the atmosphere into three-carbon sugars.
Carnivorous lineage that includes domestic dogs, wolves, foxes, jackals, dingoes, and other extant and extinct dog-like mammals.
A type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. Carcinomas are abnormal cells that divide without control and can spread to other parts of the body.
An acquired or hereditary disease of heart muscle resulting in weakening, enlargement, thickening, or rigidity of the heart.
Conditions of the heart that include diseased vessels, structural problems, and blood clots (sometimes used synonymously with Atherosclerosis).
An organism that derives its energy and nutrient requirements from a diet consisting mainly or exclusively of animal tissue, whether through predation or scavenging.
A build-up of mucus in an airway or body cavity caused by inflammation such as that associated with respiratory illnesses.
|Inflammation, Mucus, Respiratory|
|CauCau of Chile||
A young boy who had been neglected and abandoned by alcoholic parents in Chile. CauCau lived in a forest without human companionship starting around 1945 at age 7 or 9, until being “found” in 1947.
|Central Aversion System||
A neural circuit that regulates fearful, defensive and/or aggressive behavioral responses to aversive stimuli.
|Central nervous system (CNS)||
The majority of the nervous system that consists of the brain, spinal cord, retina, optic nerves, and olfactory epithelium. The CNS integrates sensory information and coordinates and influences the activity of the body in bilaterally symmetric animals (all multicellular animals except sponges and radially symmetric animals such as jellyfish).
|Cerebral Cortex (Brain)||
The outer layer of the cerebrum, composed of folded gray matter, and plays an important role in consciousness.
The largest part of the brain that contains the cerebral cortex, hippocampus, basal ganglia, and olfactory bulb.
|Basal Ganglia (Brain), Cerebral Cortex (Brain), Hippocampus (Brain), Olfactory Bulb (Brain)|
A clade of aquatic mammals consisting of whales, dolphins, and porpoises.
Proteins located in plasma membranes that form a passageway that can open or close to allow or stop the flow of particular ions across the membrane (see also receptor).
A biological junction between neurons where signals are sent from cell to the next via release of chemicals (neurotransmitters).
An infection caused by the Chikungunya virus, which is spread between people by Aedes albopictus and Aedes aegypti mosquitos. Symptoms include fever and joint pain. Chikungunya typically occurs in Africa and Asia, but recent outbreaks have been reported in Europe and the Americas.
|Aedes Mosquitos, Chikungunya Virus (CHIKV), Infection|
|Chikungunya Virus (CHIKV)||
A RNA virus that belongs to the genus Alphavirus that is primarily transmitted by two species of Aedes mosquitoes, although the virus can also be transmitted from mother to child during delivery. Before 2013, the virus was found only in Africa, Asia, Europe, and the Indian and Pacific islands. In late 2013, outbreaks occurred for the first time in the Americas in the Caribbean Islands. Chikungunya (pronounced “chik-en-gun-ye”) comes from the Kimadonde verb meaning “bent over in pain” or “contorted.”
|Aedes Mosquitos, Alphavirus, Genus, RNA virus, Virus|
|Chimpanzees (Pan troglodytes)||
One of the two species comprising the genus, Pan, having branched from bonobos ~1 million years ago. Sometimes referred to as “common chimpanzees”. Native to sub-Saharan Africa, chimpanzees are found in and around the Congo Basin (north of the Congo River) and throughout West Africa. Chimpanzees are divided into four subspecies, based on appearance and distribution. Compared to bonobos, chimpanzees are somewhat larger, more aggressive, and exhibit male social dominance.
|Bonobos (Pan paniscus)|
A bacterial disease causing severe diarrhea and dehydration, usually spread in sewage-contaminated water.
A complex of DNA and proteins (histone and adaptor proteins) forming chromosomes.
|Chromosome, DNA, Euchromatin, Heterochromatin, Protein|
The idea that the 3D conformation of chromatin and the presence or absence of regulatory proteins (and their chemical modifications) interacting with histone proteins or directly with DNA can impact whether or not, and to what level, gene expression occurs.
Discrete strands of tightly packaged chromatin.
|Allosomes, Autosomes, Chromatin, Mitochondrial DNA|
|Chronic Mountain Sickness||
A disease characterized loss of adaptation to high-altitude hypoxia. Signs include severe polycythemia (increased blood volume occupied by red blood cells) and hypoxemia (lack of oxygenation).
|Cis (molecular interactions)||
Receptors expressed on a cell surface that bind ligands on the same cell surface.
A group of organisms consisting of a common ancestor and all descendants on a particular lineage. Represents a single branch on the “tree of life.”
A branching diagram used to show hypothetical relations among groups of organisms and their hypothetical most common ancestors. It is not an evolutionary tree as it does not show how ancestors are related to descendants, nor does it show evolutionary distance or time.
Making a copy of an organism or sequence.
The process by which blood changes from liquid to a gel, forming a clot. Also known as coagulation.
Time since common ancestor.
Models evolution backward in time to infer historical population size, mutation rate, allele age, and allele frequency change by selection and drift.
At least two or more individuals jointly direct aggression at one or more conspecific targets. In humans coalitionary aggression is socially organized.
A natural alkaloid and insecticide produced by the South American coca plant that also acts as a natural stimulant.
A type of short rod-shaped Gram-negative bacteria. Some species of coccobacillus cause disease in humans.
|Bacteria, Gram-Negative and Gram-Positive Staining|
A form of genomic inheritance in which both inherited alleles (one from each parent) are expressed and contribute to the phenotype.
A sequence of three nucleotides along a DNA or RNA chain encoding a single amino acid, and start or stop.
The mental action or process of acquiring knowledge and understanding through thought, experience, and the senses.
Drugs that are used to improve memory, increase mental alertness, and concentration, and boost energy levels and wakefulness. E.g., amphetamines; nicotine; caffeine.
|Cognitive Trade-off Hypothesis||
As proposed by Tetsuro Matsuzawa, postulates that a trade-off between superior language facility at the expense of memory ability based on social life occurred during human evolution. In comparison to chimpanzees, who possess superior short-term memory abilities and no known language, humans de-emphasized short term memory for extraordinary language capacity, which may be one mechanism for increased collaboration and altruism in humans.
A universal property of human language in which a set of basic, distinct units (phonemes, syllables, or hand shapes) can be combined in many different ways.
A relationship between organisms where one derives food or other benefits from the other without hurting or helping it.
An illness that is transmittable from an infected person or animal to another person or animal through direct contact or indirectly via contaminated food, water, or a vector.
|Transmissible (Disease), Vector (Epidemiology)|
A method of evolutionary analysis that uses comparisons across independently evolved species, as a means for studying historical and physical constraints.
Capability for effective function in the environment, potential or manifested.
A phenotypic trait with variability influenced by numerous genes (each with small effects).
The principle governing the combination of meaningful linguistic elements into higher order units of meaning. Compositionality guarantees that the meaning of the whole will be determined by the meaning of its parts and rules used to combine them (Kluender, 2020).
A disease or physical abnormality present from birth.
A comprehensive map of neural connections in the brain.
The waking state and awareness of existence.
Members of the same species.
Infectious diseases that can be spread from organism to organism by direct or indirect contact. Contagious disease is a subset of communicable, infectious, and transmissible.
|Communicable (disease), Infectious (disease), Transmissible (Disease)|
A branch of neuroscience that studies the effects of meditation and other forms of contemplation.
|Continuity (aka Phyletic Gradualism)||
An evolutionary model in which change occurs gradually over time. Compare with Punctuated Equilibrium.
A group of individuals in a medical study who receive either no treatment or the standard treatment, which is compared against a group who receive the treatment being studied.
A social system in which parents and other individuals within the group provide care for offspring.
|Copy Number Variation||
A phenomenon in which sections of the genome are repeated on the same or different chromosome and the number of repeats in the genome varies between individuals in the human population. Such repeats can include functional genes.
Blockage of blood flow to the heart, caused by atherosclerosis and blood clotting in a coronary artery. The most common kind of heart attack.
A member of the large, single-stranded RNA virus family (Coronaviridae) named for their ring, or corona, shape. They are also characterized by a fatty outer lining that is covered with club-shaped spike proteins. Coronaviruses are known to infect many mammals (including us humans) and birds. Different coronaviruses are responsible for causing MERS, SARS, and COVID-19.
|Coronavirus Disease 2019 (COVID-19), Middle East Respiratory Syndrome (MERS, Protein, RNA virus, Severe Acute Respiratory Syndrome (SARS)|
|Coronavirus Disease 2019 (COVID-19)||
An infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that was first identified in December 2019 in Wuhan, China, and then spread globally, resulting in a pandemic. Common symptoms include fever, cough, fatigue, shortness of breath, loss of appetite, sputum production, and muscle and joint pains, and loss of smell and taste. Severe cases may progress to acute respiratory distress syndrome (ARDS), multi-organ failure, septic shock, and blood clots. Spread of the virus occurs between people during close contact, most often via small droplets produced by coughing, sneezing, and talking. Less commonly, people may become infected by touching a contaminated surface and then touching their face.
|Acute Respiratory Distress Syndrome (ARDS), Clotting (Blood), Infectious (disease), Pandemic, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS- CoV-2), Virus|
A segment of the cerebral cortex that carries out a given function.
A class of steroid hormones. E.g., cortisol.
|Corticotropin-releasing factor (CRF)||
A neuropeptide that regulates the hypothalamic pituitary adrenal (HPA) axis response, a major neuroendocrine system.
The family of stout-billed passerine birds (an order of birds characterized by an arrangement of toes with three forward and one backward to facilitate perching) including the crows, ravens, rooks, jackdaws, jays, magpies, treepies, choughs, and nutcrackers.
The American crow.
|Cost of transport||
How much energy it takes to move from point A to point B.
The number of reads for a given locus.
Locus where a cytosine nucleotide is followed by guanine nucleotide in the linear sequence of bases. Cytosines in CpG dinucleotides can be methylated to form 5-methyl cytosine, a common epigenetic mark.
|Cranial Neural Crest Cells||Cells that become the structures of the endocranium and face.|
Clustered regularly interspaced short palindromic repeats. A method that can mutate a specified locus.
Behavior and norms that are shared, learned, and socially transmitted.
|Cumulative Cooperative Culture||
In human culture, the accumulation of cultural modifications over time (“ratchet effect”) resulting from social learning, active teaching, social motivations for conformity, and normative sanctions against non-conformity.
|Cytidine monophospho-N-acetylneuraminic acid hydroxylase (Cmah) enzyme||
An enzyme encoded by the CMAH gene that modifies sialic acids in most mammals by modifying N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc). The enzyme modifies sialic acid in its sugar nucleotide form (CMP-Neu5Ac to CMP-Neu5Gc).
|Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene, Enzyme, N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic acid (Neu5Gc), Nucleotide, Sialic acid|
|Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) gene||
The human lineage lost the function of the CMAH gene over 2 million years ago that caused human cells to both lack Neu5Gc and carry an excess of Neu5Ac.
|N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic acid (Neu5Gc)|
A severe immune reaction in which the body releases too many cytokines into the blood too quickly. Signs and symptoms include high fever, inflammation, severe fatigue, and nausea. This may be severe or even life- threatening, leading to multiple organ failure.
A broad and loose category of small proteins secreted by certain cells of the immune system and are important in cell signaling and have an effect on other cells.
|Immune system, Protein|
|Daily energy expenditure||
Total number of calories burned in a day.
Resulting cell(s) formed when neural stem cells or progenitor cells undergo cellular division.
|Neural Stem Cell|
A Latin adverb meaning “from the new.” A new genetic variant that is the result of a mutation in a germ cell (egg or sperm) of one of the parents, or a variant that arises in the fertilized egg during embryogenesis. (See Novel)
Study of population size over time.
A tropical disease caused by the Dengue virus and spread several species of female Aedes mosquitos, especially A. aegypti. Symptoms may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin rash. Severe infections may develop into Dengue Hemorrhagic Fever or Dengue Shock Syndrome.
|Aedes Mosquitos, Dengue Hemorrhagic Fever, Dengue Shock Syndrome, Dengue Virus, Infection|
|Dengue Hemorrhagic Fever||
A severe form of Dengue Fever, which includes bleeding and blood platelet and blood plasma leakage.
|Dengue Shock Syndrome||
A severe form of Dengue Fever in which dangerously low blood pressure occurs.
The cause of Dengue Fever. It is a mosquito- borne, single positive-stranded RNA virus of the genus, Flavivirus. Origin: Africa and Asia.
|Dengue Fever, Genus, RNA virus|
An extinct hominin population contemporary with Neanderthals that hybridized with ancient humans and Neanderthals. Knowledge of Denisovan morphology is limited to two small fossils found in Siberia and a jaw in Tibet.
Calcified dental plaque, provides information on diet, disease, health, microbiome and protects the genetic information within the tooth from degradation.
|Deoxyribonucleic acid (DNA)||
The molecule of inheritance, which consists of sequences of the four nucleotide bases: Adenine, Thymine, Guanine, and Cytosine
Variants arising since last common ancestor.
An irreversible biological characteristic acquired during growth and development in a stressful environment.
A selective disorder characterized by marked impairment in episodic memory despite relatively preserved semantic memory.
Spreading effects over time across systems or domains of function that result from interactions in dynamic systems and cumulatively alter development.
Psychosocial milestones or accomplishments expected of people of different ages in a given cultural and historical context; Common developmental tasks include bonding with caregivers, walking, talking, learning to read, getting along with other people, and caring for one’s children.
|Diffusor Tensor Imaging (DTI)||
Neuroimaging of the location, orientation, and anisotropy of the brain’s white matter tracts through MRI.
|Functional Magnetic Resonance Imaging (fMRI), White Matter (Brain)|
Organisms with two sets of each chromosome except for XY sex chromosomes in male mammals.
|Chromosome, Haploid, Karyotype|
Outwardly apparent effects of a disease.
The ability to refer to entities, properties, and events at some spatial and/or temporal remove from the immediate communicative situation (Kluender, 2020).
Change in genetic content or phenotype between isolated populations or species.
Northern Chad. A fossil rich desert that is most famous for the discovery of Sahelenthropous tchadensis (Toumai) in 2001.
Deoxyribonucleic acid. The molecule of inheritance, which consists of sequences of the four nucleotide bases: Adenine, Thymine, Guanine, and Cytosine.
A process by which methyl groups are added to the DNA molecule. Methylation can change the activity of a DNA segment without changing the sequence. When located in a gene promoter, DNA methylation typically acts to repress gene transcription.
The specific order of the nucleotide bases Adenine, Thymine, Guanine, and Cytosine.